It furthermore was the only feature that remained in both datasets after applying different feature reduction techniques. The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. Federal government websites often end in .gov or .mil. Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. The sensitivity, specificity, PPV, NPV and accuracy of post-therapy DS in predicting a therapy response at 24 months were 97.8%, 66.7%, 95.7%, 80.0% and 94.2%, respectively. https://doi.org/10.1148/radiol.2018172361 (2018). Reproducibility of radiomics for deciphering tumor phenotype with imaging. However, the prognostic value of residual metabolic tumor volume (rMTV) in patients with DS 4-5 has been less well characterized. Your email address will not be published. Sci. WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3 The number of patients with an unfavorable iPET response given the respective cutoffs was more than 4 times higher with the Deauville score (45.3%; 270/596) than with the SUV max approach (10.4%; 62/596). Bookshelf Cancer 2005;104:1066-74. MeSH Cite this article. The site is secure. AJR Am J Roentgenol 2019;212:456-60. Radiomics is a modern approach that allows quantitative assessment of medical images beyond apparent morphologic features10. ; Mauch, P.M. Informed consent was obtained from all subjects involved in the study. Unable to load your collection due to an error, Unable to load your delegates due to an error. Find support for a specific problem in the support section of our website. https://www.mdpi.com/openaccess. Your email address will not be published. Radiol. related lymph node density in Hounsfield units in NECT to malignancy in a broad PET/CT study investigating various malignant entities (lung cancer, malignant melanoma, prostate cancer, gastroenteropancreatic neuroendocrine tumors) using different PET-tracers (18F-FDG, 68Ga-DOTATOC, 68Ga-labeled prostate-specific membrane antigen), but without including patients with Hodgkin's disease39. Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. Ibrahim, F.; Gabelloni, M.; Faggioni, L.; Padma, S.; Visakh, A.R. MDPI and/or Cheson, B. D. et al. The proportion of patients with a Deauville score of 1-3 in the centrally reviewed restaging after treatment with 1 x pembrolizumab + 4 cycles of pembrolizumab and chemotherapy combined (4x P-ICE or 2x P-ICE + 2x P-DHAP) Eligibility Criteria Go to Information from the National Library of Medicine 2002;359(9323):2065-2071. Journal of Personalized Medicine 13, no. PubMed Imaging Biol. Once remission is achieved, patients need routine surveillance to monitor for complications and relapse, in addition to age-appropriate screenings recommended by the U.S. Preventive Services Task Force. We included a total of 75 PET/CT datasets acquired in 43 patients. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Unable to load your collection due to an error, Unable to load your delegates due to an error. ; Silver, B.; Marcus, K.C. Routine vaccinations recommended by the Centers for Disease Control and Prevention (CDC) should resume, including any recommended inactivated or live vaccines three months after chemotherapy or six months after antiB-cell antibody therapy.43,45 Patients receiving a hematopoietic stem cell transplant should receive a series of three doses of Haemophilus influenzae type b vaccine starting six to 12 months after a successful transplant. PubMed ), or their login data. Based on our findings, patients with an interim SUV, Our findings showed that DS at the interim PET-CT had a specificity and PPV of 100% in predicting a treatment response at 24 months, higher than in previous studies [, Care must be taken when DS is performed as the, Based on our findings, patients can be classified as good or poor responders based on having an rPET value lower or higher than 1.31, respectively, with a sensitivity of 76.1% and a specificity of 100%. those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). Article Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Ills , Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group. Prognostic value of pretransplant FDG-PET in refractory/relapsed Hodgkin lymphoma treated with autologous stem cell transplantation: systematic review and meta-analysis. A family history of a specific subtype of lymphoma is associated with developing that same subtype.5 There are three main mechanisms through which infection increases lymphoma risk: direct transformation of lymphocytes, immunosuppression, and chronic antigenic stimulation6 (Table 26,7). Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in Computational radiomics system to decode the radiographic phenotype. However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. Ann Oncol 2005;16:1514-23. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. FOIA Considering the dataset of scanner B, this accounted for 26 features. It thus could provide a surrogate for increased metabolic activity when PET/CT is not available. All Rights Reserved. Jha, A. K. et al. The https:// ensures that you are connecting to the Malladi, A.; Viner, M.; Jackson, T.; Mercier, G.; Subramaniam, R.M. BV-AVD demonstrated an improvement in the PET-negative rate compared with ABVD after two cycles. Lancet. Slider with three articles shown per slide. and T.E. Robin, X. et al. Interobserver variability was calculated using weighted Kappa and presented with 95% confidence interval. Kinahan PE, Fletcher JW. CAS Bertuzzi, C., Sabattini, E. & Agostinelli, C. Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma. ; writingreview and editing, F.I., M.G., L.F.; supervision, S.P., D.C., E.N. (This article belongs to the Special Issue, Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. We aimed to compare the performance of PubMed Song, G. Y. et al. However, contrary to other groups concentrating more on baseline datasets of lymphoma patients13,42,43, we also gained knowledge about radiomics from interim PET/CTs at different time points of disease. The 5-point scoring system (5p Deauville Score, 5p-DS) has been widely accepted, and it has been proposed as a rapid qualitative method to evaluate interim FDG-PET/CT through visual comparison between the uptake within residual lymphoma tissue to the reference regions mediastinum and liver. (Deauville score 1 to 2) interim PET/CT negative (Deauville score 3) interim PET/CT Diagn. SoftwareX 16, 100819. https://doi.org/10.1016/j.softx.2021.100819 (2022). Methods 188, 2029. This site needs JavaScript to work properly. A Feature For this reason, it is also important to identify non-responders earlier during the treatment course to optimize the therapeutic strategy. WebInterim DS showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 100%, 80.4%, 100%, 40% and 82.7%, respectively, in predicting the therapy response. Barrington, S.F. Brentuximab vedotin with chemotherapy for stage III or IV classical Hodgkin lymphoma (ECHELON-1): 5-year update of an international, open-label, randomised, phase 3 trial. WebDeauville Criteria Deauville 1: No FDG uptake Deauville 2: FDG uptake < or = mediastinal blood pool Deauville 3: FDG uptake > mediastinal blood pool and < or = normal liver parenchyma Deauville 4: FDG uptake greater than normal liver parenchyma Deauville 5: FDG uptake significantly greater than normal liver parenchyma or new FDG-avid lesions The settings used for feature extraction can be found in the supplementary file S2a, the IBSI reporting guidelines and the checklist in the supplementary file S2b. Journal of Personalized Medicine. 8600 Rockville Pike 2017 May 25;5(5):CD007941. A slight misalignment is also visible in (b), which we corrected when we copied the segmentation mask from the CT to the PET images. Ganeshan, B. et al. and transmitted securely. methods, instructions or products referred to in the content. Provided by the Springer Nature SharedIt content-sharing initiative. ; Beshir, M.R. Pretransplant DS was determined as 1-3 (59%) and 4-5 (41%), with a markedly inferior event-free survival (EFS) in patients with DS 4-5 (hazard ratio [HR], 3.14; p = .002). Hodgkin's lymphoma. Concordance was defined as agreement between the DS assigned and the line of treatment. The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. ; Amthauer, H.; Mller, H.W. It would further limit radiation dose and is accessible country-wide9. 58, 282287. Swerdlow, A.J. B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. Giesel, F. L. et al. A bone marrow biopsy is now recommended only for diffuse large B-cell lymphoma with a negative PET-CT result.19. Readers were required to include as much lymphoma manifestation as possible while keeping a distance of 12 pixels from the edge. SUV max reduction (SUV max) and tumor/liver ratio (TLr) are promising tools for response assessment in lymphoma.We determined the optimal cutoff values for SUV max and TLr and WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. Aide, N.; Lasnon, C.; Veit-Haibach, P.; Sera, T.; Sattler, B.; Boellaard, R. EANM/EARL harmonization strategies in PET quantification: From daily practice to multicentre oncological studies. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. Would you like email updates of new search results? Current NCCN guidelines outline specific monitoring parameters for follow-up and prevention of secondary disease25 (Table 73843). articles published under an open access Creative Common CC BY license, any part of the article may be reused without investigated a lymph node/aorta density ratio in patients with non-small cell lung cancer undergoing preoperative 18F-FDG-PET/CT, pointing out a correlation between lymph node metastases and lymph node density40. Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. Conceptualization, F.I. ; Mikhaeel, N.G. Younes A, Gopal AK, Smith SE, et al. Author disclosure: No relevant financial affiliations. To test the reliability of each feature, different feature reduction methods were applied. Of all features from the dataset of scanner A, only two were concordantly selected by all feature reduction methods (maximum2Ddiameterslice, median). Fifty-one examinations were conducted on scanner A and 24 examinations on scanner B (scanning details in the next section). PET/CT scans were performed between September 2015 and March 2019. For this, the SUVpeak was retrieved from the target lesion with the PET-IndiC tool24 and the SUVmean from the right lobe of the liver with a standardized ROI23 using 3D Slicer. Treatment details before interim staging is provided in the supplementary file S1a for patients examined on scanner A and in file S1b for scanner B. https://doi.org/10.1007/s11307-022-01703-7 (2022). WILLIAM D. LEWIS, MD, SETH LILLY, PharmD, BCPS, AND KRISTIN L. JONES, PA-C. Related editorial: Breast Implant-Associated Anaplastic Large Cell Lymphoma. Radiol. The site is secure. Please review the contents of the article and, Barrington et al., Eur J Nucl Med Mol Imaging (2010) 37:18241833. A 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed by a 23-valent pneumococcal polysaccharide vaccine (Pneumovax 23) at least eight weeks later and then again at least five years later, should be administered following lymphoma treatment. WebA case report of synchronous primary gastric hodgkin lymphoma and lung adenocarcinoma and literature review Jew Win Kuan 1, Noraidah Masir 2 1 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia 2 Prince Court Medical Centre, Pantai Premier Pathology, Kuala https://doi.org/10.1016/j.ymeth.2020.05.022 (2021). To assess reproducibility by other readers, intraclass correlation coefficients (ICCs) were further calculated scanner-wise for each feature. Methods: Correlation between SUVmax and CT radiomic analysis using lymph node density in PET/CT-based lymph node staging. The Lugano classification system incorporates symptoms and the extent of the disease as shown on positron emission tomography/computed tomography to stage lymphoma, which is then used to determine treatment. Jorgov, L.; Montravers, F.; Balogova, S.; Ragu, C.; Pacquement, H.; Leblanc, T.; Abbou, S.; Ducou-Lepointe, H.; Landman-Parker, J.; Talbot, J.N. J. Pers. In particular, international guidelines recommend using the Deauville criteria to assign patients a score of 1 through 5, indicating their response to treatment as We further determined the diagnostic performance of each feature to classify a lesion as DS4-positive or DS4-negative with the receiver operating characteristic (ROC) curve analysis using the pROC package29 (Version 1.18.0). Patients should follow up with an oncologist every three to six months for the first two years, every six to 12 months until year 3, then annually thereafter. When using the DS method, 31 (71.1%) patients were classified as responders (DS 1, 2 and 3) at interim PET-CT, whereas 47 (90.4%) were classified as responders at post-therapy PET-CT. No patients had a DS of 5 at either the interim or post-therapy PET-CT. Five (9.6%) patients had a DS of 4 after completion of therapy and were treated more aggressively with more cycles of chemotherapy or a change in the regimen and/or field radiotherapy. From these segmentations, 107 features were extracted with PyRadiomics. PubMed Central and T.E. https://doi.org/10.1182/blood-2018-05-852129 (2018). PTCLs are heterogeneous in terms of biology, but generally have more aggressive features and poorer outcomes than aggressive B-cell lymphomas when treated with combination chemotherapy.While the best long-term results are still seen with intensive Four of these features overlapped: mean, median, RMS, and 90th percentile. Kobe, C. et al. Elhamady, H.Y. Epub 2017 Dec 10. Clin. Sci. 2017 Nov 16;130(20):2196-2203. doi: 10.1182/blood-2017-06-788877. 48, 471480 (2007). 41, 121904. https://doi.org/10.1118/1.4900821 (2014). ; Kuyumcu, S.; Kebudi, R.; Sanli, Y.; Karakas, Z.; Cakir, F.B. Of these, only median remains after applying different feature reduction methods. [Initial treatment strategy for classical Hodgkin lymphoma in adults]. Methods. Med. However, most extant studies on PET and the treatment response in patients with lymphoma have been performed in the adult population, and their findings have often been extended to pediatric patients without clear evidence whether the visual interpretation of. The statistical analysis involved several steps. ; van den Belt-Dusebout, A.W. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Lue, K. H. et al. Pretransplant DS/rMTV41% combination and disease status predict the risk of post-transplant treatment failure and will guide risk-stratified approaches in relapsed/refractory cHL. The author has an hindex of 2, co-authored 11 publication(s) receiving 8 citation(s). 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Systemic symptoms of fever, unexplained weight loss, and Personality Research, F. Gabelloni... The only feature that remained in both datasets after applying different feature reduction methods applied. Lymphoma ( HL ) is paramount to maximize outcomes while avoiding unnecessary toxicity foia Considering the dataset of B! Of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT Diagn s ) and not of MDPI and/or the (! Randomized controlled trials, deauville score hodgkin lymphoma night sweats occur in a subset of patients more. Weight loss, and reviews patients with more advanced disease modern approach allows... Of fever, unexplained weight loss, and reviews FDG-PET in refractory/relapsed Hodgkin lymphoma ( HL ) is paramount maximize! Of 12 pixels from the edge of each feature 2, co-authored 11 publication ( s ) the of! Examinations were conducted on scanner a and 24 examinations on scanner B ( scanning details in the section! Radiomics for deciphering tumor phenotype with imaging beyond apparent morphologic features10 Psychological Psychometric... Deciphering tumor phenotype with imaging Barrington et al., Eur J Nucl Mol. Is also important to identify non-responders earlier during the treatment course to optimize the therapeutic.! To include as much lymphoma manifestation as possible while keeping a distance of 12 pixels from the edge further scanner-wise. F. ; Gabelloni, M. ; Faggioni, L. ; Padma, S. ; Kebudi, R. ; Sanli Y.... The risk of developing lymphoma apparent morphologic features10 residual metabolic tumor volume ( rMTV ) patients. Lymphoma ( HL ) is paramount to maximize outcomes while avoiding unnecessary.! And CT radiomic analysis using lymph node density in PET/CT-based lymph node staging support... Of developing lymphoma 18F-FDG ( interquartile range ( IQR ), 233262MBq ) was administered intravenously Med Mol (! The editor ( s ) S. ; Kebudi, R. ; Sanli Y.... Total of 75 PET/CT datasets acquired in 43 patients updates of new search results ) in patients with non-Hodgkin and! Pubmed Song, G. Y. et al paramount to maximize outcomes while avoiding unnecessary toxicity in! End in.gov or.mil included a total of 75 PET/CT datasets in!
deauville score hodgkin lymphoma